Entries by Bradley Nash

Jared Luchetta awarded neuroAIDS fellowship

Jared Luchetta was appointed as a National Research Service Award (NRSA) pre-doctoral fellow on Drexel University’s Interdisciplinary and Translational Research Training Grant in NeuroAIDS. The training grant is funded by the National Institute of Mental Health as part of a long-standing collaboration between Drexel and Temple University investigators. Congratulations Jared!

Meucci lab publishes book chapter on opioid regulation of neuronal iron homeostasis

The Meucci lab published a book chapter on known and potential mechanisms by which µ-opioid agonists regulate neuronal iron homeostasis, a new finding that has implications for HIV-associated neurocognitive disorders and other neurological disorders. The chapter expands on previous work from our lab showing that morphine regulates iron storage in endolysosomes, and this leads to […]

Dr. Meucci contributes to article on links between COVID-19 and Parkinson’s disease

In collaboration with 15 researchers, Dr. Meucci contributed to a viewpoint article on how coronavirus disease 2019 (COVID-19) could be linked to Parkinson’s disease and Parkinsonism. The article discusses current knowledge and potential mechanisms by which SARS-CoV-2 may establish an infection in the brain, how brain infection might lead to clinical manifestations of Parkinsonism, and […]

New Meucci lab publication shows that a chemokine can enhance cognitive flexibility

The Meucci lab recently published a new study suggesting that learning and memory problems in patients with HIV-associated neurocognitive disorders (HAND) may be reversible. Using an animal model of HAND, Dr. Lindsay Festa and colleagues showed that treatment with the chemokine CXCL12 improved cognitive flexibility in a set-shifting task and increased dendritic spine density in […]

DUniBo update: “The Outlooking Scientist”

DUniBo, the new collaboration between Drexel University and the University of Bologna, Italy – led by Dr. Olimpia Meucci (DUCOM) and Dr. Renato Brandimarti (UniBo) – received funding from the University of Bologna to launch its first exchange project titled ‘The outlooking scientist’. The grant supports a visit of four graduate students (two from each […]

Morphine releases iron from storage: Research summary on Neuronline

Bradley Nash and Olimpia Meucci recently published an article on the Society for Neuroscience website Neuronline breaking down the Meucci lab’s latest research on opioid regulation of neuronal iron metabolism. The article discusses why the lab was looking into opioids effects on iron, the results of our most recent study, and how the insights gained […]

Dr. Meucci elected as a fellow of the National Academy of Inventors

Congratulations to Dr. Meucci, who has been elected as a 2019 fellow of the National Academy of Inventors (NAI)!  Each year, the NAI elects a class of academic fellows whose innovations and inventions have made a positive impact on society. The NAI fellow is the highest level of distinction for academic inventors, developed to both […]

Meucci lab publishes review article on opioid and chemokine regulation of synaptodendritic damage in HAND

The Meucci lab published a new review article that outlines the interplay between chemokine and opioid signaling and how these systems may regulate synaptodendritic damage in HIV-associated neurocognitive disorders (HAND). The article begins with a brief discussion of synaptodendritic damage in HAND and presents a small study on region-specific synaptic damage in two animal models […]

Ipek Eralp wins 2nd place at Discovery Day 2019 poster competition

Congratulations to Ipek Eralp, who won second place in the junior graduate students poster competition at Discovery Day 2019! Ipek’s poster was titled: Morphine regulation of the iron-dependent protein ferritin heavy chain in cortical neurons: is there a role for the divalent metal transporter-1? For more information, as well as a complete list of Discovery […]

Meucci Lab publishes new collaborative study on the role of iron in neuronal opioid signaling

In collaboration with Dr. Jonathan Geiger’s lab at the University of North Dakota, the Meucci lab recently published a new study describing how iron contributes to opioid-induced morphological changes in cortical neurons. Interestingly, morphine caused the release of iron stored in neuronal endolysosomes to the cytoplasm, which led to a post-transcriptional upregulation of the iron […]