Publications

  1. Dou, Y, Xia, J, Gao, R, Gao, X, Munoz, FM, Wei, D, Tian, Y, Barrett, JE, Ajit, S, Meucci, O, Putney, JW Jr, Dai, Y, Hu, H. 2017. Orai1 plays a crucial role in central sensitization by modulating neuronal excitability. J. Neurosci. :.
  2. Brandimarti, R, Hill, GS, Geiger, JD, Meucci, O. 2017. The lipid raft-dwelling protein US9 can be manipulated to target APP compartmentalization, APP processing, and neurodegenerative disease pathogenesis. Sci Rep 7:15103.
  3. Gao, X, Xia, J, Munoz, FM, Manners, MT, Pan, R, Meucci, O, Dai, Y, Hu, H. 2016. STIMs and Orai1 regulate cytokine production in spinal astrocytes. J Neuroinflammation 13:126.
  4. Shen, F, Zhang, Y, Jernigan, DL, Feng, X, Yan, J, Garcia, FU, Meucci, O, Salvino, JM, Fatatis, A. 2016. Novel Small-Molecule CX3CR1 Antagonist Impairs Metastatic Seeding and Colonization of Breast Cancer Cells. Mol. Cancer Res. 14:518-27.
  5. Wurth, R, Tarn, K, Jernigan, D, Fernandez, SV, Cristofanilli, M, Fatatis, A, Meucci, O. 2015. A Preclinical Model of Inflammatory Breast Cancer to Study the Involvement of CXCR4 and ACKR3 in the Metastatic Process. Transl Oncol 8:358-67.
  6. Festa, L, Gutoskey, CJ, Graziano, A, Waterhouse, BD, Meucci, O. 2015. Induction of Interleukin-1β by Human Immunodeficiency Virus-1 Viral Proteins Leads to Increased Levels of Neuronal Ferritin Heavy Chain, Synaptic Injury, and Deficits in Flexible Attention. J. Neurosci. 35:10550-61.
  7. Strazza, M, Banerjee, A, Alexaki, A, Passic, SR, Meucci, O, Pirrone, V, Wigdahl, B, Nonnemacher, MR. 2014. Effect of μ-opioid agonist DAMGO on surface CXCR4 and HIV-1 replication in TF-1 human bone marrow progenitor cells. BMC Res Notes 7:752.
  8. Nash, B, Meucci, O. 2014. Functions of the chemokine receptor CXCR4 in the central nervous system and its regulation by μ-opioid receptors. Int. Rev. Neurobiol. 118:105-28.
  9. Pedrazzi, M, Nash, B, Meucci, O, Brandimarti, R. 2014. Molecular features contributing to virus-independent intracellular localization and dynamic behavior of the herpesvirus transport protein US9. PLoS ONE 9:e104634.
  10. Xia, J, Pan, R, Gao, X, Meucci, O, Hu, H. 2014. Native store-operated calcium channels are functionally expressed in mouse spinal cord dorsal horn neurons and regulate resting calcium homeostasis. J. Physiol. (Lond.) 592:3443-61.
  11. Pitcher, J, Abt, A, Myers, J, Han, R, Snyder, M, Graziano, A, Festa, L, Kutzler, M, Garcia, F, Gao, WJ, Fischer-Smith, T, Rappaport, J, Meucci, O. 2014. Neuronal ferritin heavy chain and drug abuse affect HIV-associated cognitive dysfunction. J. Clin. Invest. 124:656-69.
  12. Pitcher, J, Wurth, R, Shimizu, S, Meucci, O. 2013. Multispectral imaging and automated laser capture microdissection of human cortical neurons: a quantitative study of CXCR4 expression. Methods Mol. Biol. 1013:31-48.
  13. Festa, L, Meucci, O. 2012. Effects of opiates and HIV proteins on neurons: the role of ferritin heavy chain and a potential for synergism. Curr. HIV Res. 10:453-62.
  14. Shimizu, S, Abt, A, Meucci, O. 2011. Bilaminar co-culture of primary rat cortical neurons and glia. J Vis Exp :.
  15. Jamieson-Gladney, WL, Zhang, Y, Fong, AM, Meucci, O, Fatatis, A. 2011. The chemokine receptor CX₃CR1 is directly involved in the arrest of breast cancer cells to the skeleton. Breast Cancer Res. 13:R91.
  16. Banerjee, A, Strazza, M, Wigdahl, B, Pirrone, V, Meucci, O, Nonnemacher, MR. 2011. Role of mu-opioids as cofactors in human immunodeficiency virus type 1 disease progression and neuropathogenesis. J. Neurovirol. 17:291-302.
  17. Shimizu, S, Brown, M, Sengupta, R, Penfold, ME, Meucci, O. 2011. CXCR7 protein expression in human adult brain and differentiated neurons. PLoS ONE 6:e20680.
  18. Abt, AC, Meucci, O. 2011. Regulation of neuronal ferritin heavy chain, a new player in opiate-induced chemokine dysfunction. J Neuroimmune Pharmacol 6:466-76.
  19. Nicolai, J, Burbassi, S, Rubin, J, Meucci, O. 2010. CXCL12 inhibits expression of the NMDA receptor's NR2B subunit through a histone deacetylase-dependent pathway contributing to neuronal survival. Cell Death Dis 1:e33.
  20. Burbassi, S, Sengupta, R, Meucci, O. 2010. Alterations of CXCR4 function in μ-opioid receptor-deficient glia. Eur. J. Neurosci. 32:1278-88.
  21. Pitcher, J, Shimizu, S, Burbassi, S, Meucci, O. 2010. Disruption of neuronal CXCR4 function by opioids: preliminary evidence of ferritin heavy chain as a potential etiological agent in neuroAIDS. J. Neuroimmunol. 224:66-71.
  22. Khan, MZ, Vaidya, A, Meucci, O. 2011. CXCL12-mediated regulation of ANP32A/Lanp, a component of the inhibitor of histone acetyl transferase (INHAT) complex, in cortical neurons. J Neuroimmune Pharmacol 6:163-70.
  23. Cook, A, Hippensteel, R, Shimizu, S, Nicolai, J, Fatatis, A, Meucci, O. 2010. Interactions between chemokines: regulation of fractalkine/CX3CL1 homeostasis by SDF/CXCL12 in cortical neurons. J. Biol. Chem. 285:10563-71.
  24. Busillo, JM, Armando, S, Sengupta, R, Meucci, O, Bouvier, M, Benovic, JL. 2010. Site-specific phosphorylation of CXCR4 is dynamically regulated by multiple kinases and results in differential modulation of CXCR4 signaling. J. Biol. Chem. 285:7805-17.
  25. Sengupta, R, Burbassi, S, Shimizu, S, Cappello, S, Vallee, RB, Rubin, JB, Meucci, O. 2009. Morphine increases brain levels of ferritin heavy chain leading to inhibition of CXCR4-mediated survival signaling in neurons. J. Neurosci. 29:2534-44.
  26. Khan, MZ, Brandimarti, R, Shimizu, S, Nicolai, J, Crowe, E, Meucci, O. 2008. The chemokine CXCL12 promotes survival of postmitotic neurons by regulating Rb protein. Cell Death Differ. 15:1663-72.
  27. Jamieson, WL, Shimizu, S, D'Ambrosio, JA, Meucci, O, Fatatis, A. 2008. CX3CR1 is expressed by prostate epithelial cells and androgens regulate the levels of CX3CL1/fractalkine in the bone marrow: potential role in prostate cancer bone tropism. Cancer Res. 68:1715-22.
  28. Burbassi, S, Aloyo, VJ, Simansky, KJ, Meucci, O. 2008. GTPgammaS incorporation in the rat brain: a study on mu-opioid receptors and CXCR4. J Neuroimmune Pharmacol 3:26-34.
  29. Jain, P, Ahuja, J, Khan, ZK, Shimizu, S, Meucci, O, Jennings, SR, Wigdahl, B. 2007. Modulation of dendritic cell maturation and function by the Tax protein of human T cell leukemia virus type 1. J. Leukoc. Biol. 82:44-56.
  30. Patel, JP, Sengupta, R, Bardi, G, Khan, MZ, Mullen-Przeworski, A, Meucci, O. 2006. Modulation of neuronal CXCR4 by the micro-opioid agonist DAMGO. J. Neurovirol. 12:492-500.
  31. Shimizu, S, Khan, MZ, Hippensteel, RL, Parkar, A, Raghupathi, R, Meucci, O. 2007. Role of the transcription factor E2F1 in CXCR4-mediated neurotoxicity and HIV neuropathology. Neurobiol. Dis. 25:17-26.
  32. Bardi, G, Sengupta, R, Khan, MZ, Patel, JP, Meucci, O. 2006. Human immunodeficiency virus gp120-induced apoptosis of human neuroblastoma cells in the absence of CXCR4 internalization. J. Neurovirol. 12:211-8.
  33. Dolloff, NG, Shulby, SS, Nelson, AV, Stearns, ME, Johannes, GJ, Thomas, JD, Meucci, O, Fatatis, A. 2005. Bone-metastatic potential of human prostate cancer cells correlates with Akt/PKB activation by alpha platelet-derived growth factor receptor. Oncogene 24:6848-54.
  34. Khan, MZ, Shimizu, S, Patel, JP, Nelson, A, Le, MT, Mullen-Przeworski, A, Brandimarti, R, Fatatis, A, Meucci, O. 2005. Regulation of neuronal P53 activity by CXCR 4. Mol. Cell. Neurosci. 30:58-66.
  35. Khan, MZ, Brandimarti, R, Patel, JP, Huynh, N, Wang, J, Huang, Z, Fatatis, A, Meucci, O. 2004. Apoptotic and antiapoptotic effects of CXCR4: is it a matter of intrinsic efficacy? Implications for HIV neuropathogenesis. AIDS Res. Hum. Retroviruses 20:1063-71.
  36. Shulby, SA, Dolloff, NG, Stearns, ME, Meucci, O, Fatatis, A. 2004. CX3CR1-fractalkine expression regulates cellular mechanisms involved in adhesion, migration, and survival of human prostate cancer cells. Cancer Res. 64:4693-8.
  37. Brandimarti, R, Khan, MZ, Fatatis, A, Meucci, O. 2004. Regulation of cell cycle proteins by chemokine receptors: A novel pathway in human immunodeficiency virus neuropathogenesis?. J. Neurovirol. 10 Suppl 1:108-12.
  38. Khan, MZ, Brandimarti, R, Musser, BJ, Resue, DM, Fatatis, A, Meucci, O. 2003. The chemokine receptor CXCR4 regulates cell-cycle proteins in neurons. J. Neurovirol. 9:300-14.
  39. Roncarati, R, Sestan, N, Scheinfeld, MH, Berechid, BE, Lopez, PA, Meucci, O, McGlade, JC, Rakic, P, D'Adamio, L. 2002. The gamma-secretase-generated intracellular domain of beta-amyloid precursor protein binds Numb and inhibits Notch signaling. Proc. Natl. Acad. Sci. U.S.A. 99:7102-7.
  40. Meucci, O, Fatatis, A, Simen, AA, Miller, RJ. 2000. Expression of CX3CR1 chemokine receptors on neurons and their role in neuronal survival. Proc. Natl. Acad. Sci. U.S.A. 97:8075-80.
  41. Miller, RJ, Meucci, O. 1999. AIDS and the brain: is there a chemokine connection?. Trends Neurosci. 22:471-9.
  42. Tran, PB, Meucci, O, Miller, RJ. 1999. HIV-1 and chemokines in the brain: location, location--location?. Mol. Psychiatry 4:203-5, 202.
  43. Meucci, O, Miller, RJ. Dissociation between the Joro spider toxin sensitivity of recombinant alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors and their ability to increase intracellular calcium. Neuropharmacology 37:1431-43.
  44. Meucci, O, Fatatis, A, Simen, AA, Bushell, TJ, Gray, PW, Miller, RJ. 1998. Chemokines regulate hippocampal neuronal signaling and gp120 neurotoxicity. Proc. Natl. Acad. Sci. U.S.A. 95:14500-5.
  45. Scorziello, A, Meucci, O, Calvani, M, Schettini, G. 1997. Acetyl-L-carnitine arginine amide prevents beta 25-35-induced neurotoxicity in cerebellar granule cells. Neurochem. Res. 22:257-65.
  46. Meucci, O, Miller, RJ. 1996. gp120-induced neurotoxicity in hippocampal pyramidal neuron cultures: protective action of TGF-beta1. J. Neurosci. 16:4080-8.
  47. Scorziello, A, Meucci, O, Florio, T, Fattore, M, Forloni, G, Salmona, M, Schettini, G. 1996. beta 25-35 alters calcium homeostasis and induces neurotoxicity in cerebellar granule cells. J. Neurochem. 66:1995-2003.
  48. Meucci, O, Fatatis, A, Holzwarth, JA, Miller, RJ. 1996. Developmental regulation of the toxin sensitivity of Ca(2+)-permeable AMPA receptors in cortical glia. J. Neurosci. 16:519-30.
  49. Ventra, C, Meucci, O, Grimaldi, M, Scorziello, A, Porcellini, A, Schettini, G. 1995. Absence of D2S dopamine receptor in the prolactin-secreting MMQ pituitary clone: characterization of a wild D2L receptor coupled to native transduction mechanisms. J. Mol. Endocrinol. 14:375-89.
  50. Meucci, O, Scorziello, A, Avallone, A, Florio, T, D'Alto, V, Fattore, M, Schettini, G. 1995. Alpha 1 B, but not alpha 1A, adrenoreceptor activates calcium influx through the stimulation of a tyrosine kinase/phosphotyrosine phosphatase pathway, following noradrenaline-induced emptying of IP3 sensitive calcium stores, in PC Cl3 rat thyroid cell line. Biochem. Biophys. Res. Commun. 209:630-8.
  51. Galli, C, Meucci, O, Scorziello, A, Werge, TM, Calissano, P, Schettini, G. 1995. Apoptosis in cerebellar granule cells is blocked by high KCl, forskolin, and IGF-1 through distinct mechanisms of action: the involvement of intracellular calcium and RNA synthesis. J. Neurosci. 15:1172-9.
  52. Ventra, C, Grimaldi, M, Meucci, O, Scorziello, A, Apicella, A, Filetti, E, Marino, A, Schettini, G. 1994. Aniracetam improves behavioural responses and facilitates signal transduction in the rat brain. J. Psychopharmacol. (Oxford) 8:109-17.
  53. Meucci, O, Scorziello, A, Avallone, A, Ventra, C, Grimaldi, M, Berlingieri, MT, Fusco, A, Schettini, G. 1994. Alpha 1A- and alpha 1B-adrenergic receptors mediate the effect of norepinephrine on cytosolic calcium levels in rat PC C13 thyroid cells: thyrotropin modulation of alpha 1B-linked response via a adenosine 3',5'-monophosphate-protein kinase-A-dependent pathway. Endocrinology 134:424-31.
  54. Scorziello, A, Landolfi, E, Grimaldi, M, Meucci, O, Ventra, C, Avallone, A, Postiglione, A, Schettini, G. 1993. Direct effect of adenosine on prolactin secretion at the level of the single rat lactotroph: involvement of pertussis toxin-sensitive and -insensitive transducing mechanisms. J. Mol. Endocrinol. 11:325-34.
  55. Florio, T, Meucci, O, Grimaldi, M, Ventra, C, Cocozza, E, Avallone, A, Postiglione, A, Marino, A, Schettini, G. 1993. Effect of acetyl-L-carnitine treatment on brain adenylate cyclase activity in young and aged rats. Eur Neuropsychopharmacol 3:95-101.
  56. Meucci, O, Berlingieri, MT, Fusco, A, Scorziello, A, Santoro, M, Grieco, M, Grimaldi, M, Schettini, G. 1993. Norepinephrine and thyrotropin stimulation of [Ca++]i in PC C13 a rat thyroid epithelial cell line: effect of transformation by E1A gene adenovirus and polyomavirus middle-T antigen gene. Life Sci. 52:891-9.
  57. Schettini, G, Ventra, C, Florio, T, Grimaldi, M, Meucci, O, Marino, A. 1992. Modulation by GTP of basal and agonist-stimulated striatal adenylate cyclase activity following chronic blockade of D1 and D2 dopamine receptors: involvement of G proteins in the development of receptor supersensitivity. J. Neurochem. 59:1667-74.
  58. Meucci, O, Landolfi, E, Scorziello, A, Grimaldi, M, Ventra, C, Florio, T, Avallone, A, Schettini, G. 1992. Dopamine and somatostatin inhibition of prolactin secretion from MMQ pituitary cells: role of adenosine triphosphate-sensitive potassium channels. Endocrinology 131:1942-7.
  59. Schettini, G, Ventra, C, Florio, T, Grimaldi, M, Meucci, O, Scorziello, A, Postiglione, A, Marino, A. 1992. Molecular mechanisms mediating the effects of L-alpha-glycerylphosphorylcholine, a new cognition-enhancing drug, on behavioral and biochemical parameters in young and aged rats. Pharmacol. Biochem. Behav. 43:139-51.
  60. Meucci, O, Grimaldi, M, Scorziello, A, Govoni, S, Bergamaschi, S, Yasumoto, T, Schettini, G. 1992. Maitotoxin-induced intracellular calcium rise in PC12 cells: involvement of dihydropyridine-sensitive and omega-conotoxin-sensitive calcium channels and phosphoinositide breakdown. J. Neurochem. 59:679-88.
  61. Grimaldi, M, Meucci, O, Scorziello, A, Florio, T, Ventra, C, De Mercato, R, Schettini, G. 1992. Interleukin 6 modulation of second messenger systems in anterior pituitary cells. Life Sci. 51:1243-8.
  62. Schettini, G, Grimaldi, M, Landolfi, E, Meucci, O, Ventra, C, Florio, T, Scorziello, A, Marino, A. 1991. Role of interleukin-6 in the neuroendocrine system. Acta Neurol (Napoli) 13:361-7.
  63. Schettini, G, Meucci, O, Grimaldi, M, Florio, T, Landolfi, E, Scorziello, A, Ventra, C. 1991. Dihydropyridine modulation of voltage-activated calcium channels in PC12 cells: effect of pertussis toxin pretreatment. J. Neurochem. 56:805-11.
  64. Meucci, O, Grimaldi, M, Florio, T, Landolfi, E, Ventra, C, Scorziello, A, Marino, A, Schettini, G. Cytosolic calcium rise induced by maitotoxin in PC12 cells: effect of omega-conotoxin (GVIA). Pharmacol. Res. 22 Suppl 1:75-6.
  65. Grimaldi, M, Landolfi, E, Meucci, O, Florio, T, Ventra, C, Schettini, G, Marino, A. Interleukin 1 beta modulation of TRH stimulated prolactin secretion and inositol phosphate production. Pharmacol. Res. 22 Suppl 1:81-2.
  66. Florio, T, Landolfi, E, Grimaldi, M, Meucci, O, Ventra, C, Scorziello, A, Marino, A, Schettini, G. Interleukin-6 mediates neural-immune interactions: study on prolactin release and intracellular transducing mechanisms. Pharmacol. Res. 22 Suppl 3:54.
  67. Schettini, G, Landolfi, E, Meucci, O, Florio, T, Grimaldi, M, Ventra, C, Marino, A. 1990. Adenosine and its analogue (-)-N6-R-phenyl-isopropyladenosine modulate anterior pituitary adenylate cyclase activity and prolactin secretion in the rat. J. Mol. Endocrinol. 5:69-76.
  68. Schettini, G, Florio, T, Meucci, O, Landolfi, E, Grimaldi, M, Lombardi, G, Scala, G, Leong, D. 1990. Interleukin-1-beta modulation of prolactin secretion from rat anterior pituitary cells: involvement of adenylate cyclase activity and calcium mobilization. Endocrinology 126:1435-41.
  69. Marino, A, Florio, T, Meucci, O, Landolfi, E, Grimaldi, M, Ventra, C, Schettini, G. Fipexide improvement of cognitive functions in rat: behavioural and neurochemical studies. Pharmacol. Res. 22:179-87.
  70. Meucci, O, Grimaldi, M, Landolfi, E, Scorziello, A, Marino, A, Schettini, G. 1990. How maitotoxin increases cytosolic calcium levels?. Acta Physiol Hung 75 Suppl:207-8.
  71. Bergamaschi, S, Trabucchi, M, Battaini, F, Parenti, M, Schettini, G, Meucci, O, Govoni, S. 1990. Modulation of dihydropyridine-sensitive calcium channels: a role for G proteins. Eur. Neurol. 30 Suppl 2:16-20; discussion 39-41.
  72. Schettini, G, Landolfi, E, Grimaldi, M, Meucci, O, Postiglione, A, Florio, T, Ventra, C. 1989. Interleukin 1 beta inhibition of TRH-stimulated prolactin secretion and phosphoinositides metabolism. Biochem. Biophys. Res. Commun. 165:496-505.
  73. Landolfi, E, Meucci, O, Florio, T, Grimaldi, M, Marino, A, Schettini, G. Anterior pituitary adenosine receptors, coupled to adenylate cyclase, modulate prolactin release. Pharmacol. Res. 21 Suppl 1:5-6.
  74. Florio, T, Meucci, O, Landolfi, E, Grimaldi, M, Ventra, C, Scorziello, A, Marino, A, Schettini, G. Interleukin I modulation of anterior pituitary function: effect on hormone release and second messenger systems. Pharmacol. Res. 21 Suppl 1:35-6.
  75. Meucci, O, Grimaldi, M, Florio, T, Landolfi, E, Scorziello, A, Ventra, C, Marino, A, Schettini, G. Dihydropiridine inhibition of K+ and maitotoxin stimulated calcium fluxes in PC12 cells: effect of pertussis toxin. Pharmacol. Res. 21 Suppl 1:1-2.
  76. Schettini, G, Florio, T, Meucci, O, Landolfi, E, Grimaldi, M, Ventra, C, Marino, A. 1989. Somatostatin inhibition of adenylate cyclase activity in different brain areas. Brain Res. 492:65-71.
  77. Landolfi, E, Florio, T, Meucci, O, Grimaldi, M, Magri, G, Leong, DA, Schettini, G. 1988. Steroid modulation of prolactin release from single lactotropes in male and female rats studied by the reverse hemolytic plaque assay. Pharmacol Res Commun 20:1075-6.
  78. Meucci, O, Florio, T, Grimaldi, M, Landolfi, E, Magri, G, Schettini, G. 1988. Role of G-proteins in mediating dihydropyridine receptor coupling with voltage sensitive calcium channels. Pharmacol Res Commun 20:1083-4.
  79. Schettini, G, Florio, T, Meucci, O, Scala, G, Landolfi, E, Grimaldi, M. 1988. Effect of interleukin 1 beta on transducing mechanisms in 235-1 clonal pituitary cells. Part I: Modulation of adenylate cyclase activity. Biochem. Biophys. Res. Commun. 155:1089-96.
  80. Schettini, G, Meucci, O, Florio, T, Scala, G, Landolfi, E, Grimaldi, M. 1988. Effect of interleukin 1 beta on transducing mechanisms in 235-1 clonal pituitary cells. Part II: Modulation of calcium fluxes. Biochem. Biophys. Res. Commun. 155:1097-104.
  81. Schettini, G, Florio, T, Magri, G, Grimaldi, M, Meucci, O, Landolfi, E, Marino, A. 1988. Somatostatin and SMS 201-995 reverse the impairment of cognitive functions induced by cysteamine depletion of brain somatostatin. Eur. J. Pharmacol. 151:399-407.
  82. Schettini, G, Meucci, O, Florio, T, Grimaldi, M, Landolfi, E, Magri, G, Yasumoto, T. 1988. Pertussis toxin pretreatment abolishes dihydropyridine inhibition of calcium flux in the 235-1 pituitary cell line. Biochem. Biophys. Res. Commun. 151:361-9.
  83. Schettini, G, Florio, T, Meucci, O, Landolfi, E, Lombardi, G, Marino, A. 1988. Somatostatin inhibition of anterior pituitary adenylate cyclase activity: different sensitivity between male and female rats. Brain Res. 439:322-9.
  84. Schettini, G, Florio, T, Meucci, O, Landolfi, E, Cronin, MJ, MacLeod, RM. 1987. Calmodulin modulates prolactin secretion in vitro: studies with calmodulin containing liposomes. Life Sci. 41:2437-44.
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