1. Dou, Y, Xia, J, Gao, R, Gao, X, Munoz, FM, Wei, D, Tian, Y, Barrett, JE, Ajit, S, Meucci, O, Putney, JW Jr, Dai, Y, Hu, H. 2018. Orai1 Plays a Crucial Role in Central Sensitization by Modulating Neuronal Excitability. J. Neurosci. 38:887-900.
  2. Brandimarti, R, Hill, GS, Geiger, JD, Meucci, O. 2017. The lipid raft-dwelling protein US9 can be manipulated to target APP compartmentalization, APP processing, and neurodegenerative disease pathogenesis. Sci Rep 7:15103.
  3. Gao, X, Xia, J, Munoz, FM, Manners, MT, Pan, R, Meucci, O, Dai, Y, Hu, H. 2016. STIMs and Orai1 regulate cytokine production in spinal astrocytes. J Neuroinflammation 13:126.
  4. Shen, F, Zhang, Y, Jernigan, DL, Feng, X, Yan, J, Garcia, FU, Meucci, O, Salvino, JM, Fatatis, A. 2016. Novel Small-Molecule CX3CR1 Antagonist Impairs Metastatic Seeding and Colonization of Breast Cancer Cells. Mol. Cancer Res. 14:518-27.
  5. Wurth, R, Tarn, K, Jernigan, D, Fernandez, SV, Cristofanilli, M, Fatatis, A, Meucci, O. 2015. A Preclinical Model of Inflammatory Breast Cancer to Study the Involvement of CXCR4 and ACKR3 in the Metastatic Process. Transl Oncol 8:358-67.
  6. Festa, L, Gutoskey, CJ, Graziano, A, Waterhouse, BD, Meucci, O. 2015. Induction of Interleukin-1β by Human Immunodeficiency Virus-1 Viral Proteins Leads to Increased Levels of Neuronal Ferritin Heavy Chain, Synaptic Injury, and Deficits in Flexible Attention. J. Neurosci. 35:10550-61.
  7. Strazza, M, Banerjee, A, Alexaki, A, Passic, SR, Meucci, O, Pirrone, V, Wigdahl, B, Nonnemacher, MR. 2014. Effect of μ-opioid agonist DAMGO on surface CXCR4 and HIV-1 replication in TF-1 human bone marrow progenitor cells. BMC Res Notes 7:752.
  8. Nash, B, Meucci, O. 2014. Functions of the chemokine receptor CXCR4 in the central nervous system and its regulation by μ-opioid receptors. Int. Rev. Neurobiol. 118:105-28.
  9. Pedrazzi, M, Nash, B, Meucci, O, Brandimarti, R. 2014. Molecular features contributing to virus-independent intracellular localization and dynamic behavior of the herpesvirus transport protein US9. PLoS ONE 9:e104634.
  10. Xia, J, Pan, R, Gao, X, Meucci, O, Hu, H. 2014. Native store-operated calcium channels are functionally expressed in mouse spinal cord dorsal horn neurons and regulate resting calcium homeostasis. J. Physiol. (Lond.) 592:3443-61.
  11. Pitcher, J, Abt, A, Myers, J, Han, R, Snyder, M, Graziano, A, Festa, L, Kutzler, M, Garcia, F, Gao, WJ, Fischer-Smith, T, Rappaport, J, Meucci, O. 2014. Neuronal ferritin heavy chain and drug abuse affect HIV-associated cognitive dysfunction. J. Clin. Invest. 124:656-69.
  12. Pitcher, J, Wurth, R, Shimizu, S, Meucci, O. 2013. Multispectral imaging and automated laser capture microdissection of human cortical neurons: a quantitative study of CXCR4 expression. Methods Mol. Biol. 1013:31-48.
  13. Festa, L, Meucci, O. 2012. Effects of opiates and HIV proteins on neurons: the role of ferritin heavy chain and a potential for synergism. Curr. HIV Res. 10:453-62.
  14. Shimizu, S, Abt, A, Meucci, O. 2011. Bilaminar co-culture of primary rat cortical neurons and glia. J Vis Exp :.
  15. Jamieson-Gladney, WL, Zhang, Y, Fong, AM, Meucci, O, Fatatis, A. 2011. The chemokine receptor CX₃CR1 is directly involved in the arrest of breast cancer cells to the skeleton. Breast Cancer Res. 13:R91.
  16. Banerjee, A, Strazza, M, Wigdahl, B, Pirrone, V, Meucci, O, Nonnemacher, MR. 2011. Role of mu-opioids as cofactors in human immunodeficiency virus type 1 disease progression and neuropathogenesis. J. Neurovirol. 17:291-302.
  17. Shimizu, S, Brown, M, Sengupta, R, Penfold, ME, Meucci, O. 2011. CXCR7 protein expression in human adult brain and differentiated neurons. PLoS ONE 6:e20680.
  18. Abt, AC, Meucci, O. 2011. Regulation of neuronal ferritin heavy chain, a new player in opiate-induced chemokine dysfunction. J Neuroimmune Pharmacol 6:466-76.
  19. Nicolai, J, Burbassi, S, Rubin, J, Meucci, O. 2010. CXCL12 inhibits expression of the NMDA receptor's NR2B subunit through a histone deacetylase-dependent pathway contributing to neuronal survival. Cell Death Dis 1:e33.
  20. Burbassi, S, Sengupta, R, Meucci, O. 2010. Alterations of CXCR4 function in μ-opioid receptor-deficient glia. Eur. J. Neurosci. 32:1278-88.
  21. Pitcher, J, Shimizu, S, Burbassi, S, Meucci, O. 2010. Disruption of neuronal CXCR4 function by opioids: preliminary evidence of ferritin heavy chain as a potential etiological agent in neuroAIDS. J. Neuroimmunol. 224:66-71.
  22. Khan, MZ, Vaidya, A, Meucci, O. 2011. CXCL12-mediated regulation of ANP32A/Lanp, a component of the inhibitor of histone acetyl transferase (INHAT) complex, in cortical neurons. J Neuroimmune Pharmacol 6:163-70.
  23. Cook, A, Hippensteel, R, Shimizu, S, Nicolai, J, Fatatis, A, Meucci, O. 2010. Interactions between chemokines: regulation of fractalkine/CX3CL1 homeostasis by SDF/CXCL12 in cortical neurons. J. Biol. Chem. 285:10563-71.
  24. Busillo, JM, Armando, S, Sengupta, R, Meucci, O, Bouvier, M, Benovic, JL. 2010. Site-specific phosphorylation of CXCR4 is dynamically regulated by multiple kinases and results in differential modulation of CXCR4 signaling. J. Biol. Chem. 285:7805-17.
  25. Sengupta, R, Burbassi, S, Shimizu, S, Cappello, S, Vallee, RB, Rubin, JB, Meucci, O. 2009. Morphine increases brain levels of ferritin heavy chain leading to inhibition of CXCR4-mediated survival signaling in neurons. J. Neurosci. 29:2534-44.
  26. Khan, MZ, Brandimarti, R, Shimizu, S, Nicolai, J, Crowe, E, Meucci, O. 2008. The chemokine CXCL12 promotes survival of postmitotic neurons by regulating Rb protein. Cell Death Differ. 15:1663-72.
  27. Jamieson, WL, Shimizu, S, D'Ambrosio, JA, Meucci, O, Fatatis, A. 2008. CX3CR1 is expressed by prostate epithelial cells and androgens regulate the levels of CX3CL1/fractalkine in the bone marrow: potential role in prostate cancer bone tropism. Cancer Res. 68:1715-22.
  28. Burbassi, S, Aloyo, VJ, Simansky, KJ, Meucci, O. 2008. GTPgammaS incorporation in the rat brain: a study on mu-opioid receptors and CXCR4. J Neuroimmune Pharmacol 3:26-34.
  29. Jain, P, Ahuja, J, Khan, ZK, Shimizu, S, Meucci, O, Jennings, SR, Wigdahl, B. 2007. Modulation of dendritic cell maturation and function by the Tax protein of human T cell leukemia virus type 1. J. Leukoc. Biol. 82:44-56.
  30. Patel, JP, Sengupta, R, Bardi, G, Khan, MZ, Mullen-Przeworski, A, Meucci, O. 2006. Modulation of neuronal CXCR4 by the micro-opioid agonist DAMGO. J. Neurovirol. 12:492-500.
  31. Shimizu, S, Khan, MZ, Hippensteel, RL, Parkar, A, Raghupathi, R, Meucci, O. 2007. Role of the transcription factor E2F1 in CXCR4-mediated neurotoxicity and HIV neuropathology. Neurobiol. Dis. 25:17-26.
  32. Bardi, G, Sengupta, R, Khan, MZ, Patel, JP, Meucci, O. 2006. Human immunodeficiency virus gp120-induced apoptosis of human neuroblastoma cells in the absence of CXCR4 internalization. J. Neurovirol. 12:211-8.
  33. Dolloff, NG, Shulby, SS, Nelson, AV, Stearns, ME, Johannes, GJ, Thomas, JD, Meucci, O, Fatatis, A. 2005. Bone-metastatic potential of human prostate cancer cells correlates with Akt/PKB activation by alpha platelet-derived growth factor receptor. Oncogene 24:6848-54.
  34. Khan, MZ, Shimizu, S, Patel, JP, Nelson, A, Le, MT, Mullen-Przeworski, A, Brandimarti, R, Fatatis, A, Meucci, O. 2005. Regulation of neuronal P53 activity by CXCR 4. Mol. Cell. Neurosci. 30:58-66.
  35. Khan, MZ, Brandimarti, R, Patel, JP, Huynh, N, Wang, J, Huang, Z, Fatatis, A, Meucci, O. 2004. Apoptotic and antiapoptotic effects of CXCR4: is it a matter of intrinsic efficacy? Implications for HIV neuropathogenesis. AIDS Res. Hum. Retroviruses 20:1063-71.
  36. Shulby, SA, Dolloff, NG, Stearns, ME, Meucci, O, Fatatis, A. 2004. CX3CR1-fractalkine expression regulates cellular mechanisms involved in adhesion, migration, and survival of human prostate cancer cells. Cancer Res. 64:4693-8.
  37. Brandimarti, R, Khan, MZ, Fatatis, A, Meucci, O. 2004. Regulation of cell cycle proteins by chemokine receptors: A novel pathway in human immunodeficiency virus neuropathogenesis?. J. Neurovirol. 10 Suppl 1:108-12.
  38. Khan, MZ, Brandimarti, R, Musser, BJ, Resue, DM, Fatatis, A, Meucci, O. 2003. The chemokine receptor CXCR4 regulates cell-cycle proteins in neurons. J. Neurovirol. 9:300-14.
  39. Roncarati, R, Sestan, N, Scheinfeld, MH, Berechid, BE, Lopez, PA, Meucci, O, McGlade, JC, Rakic, P, D'Adamio, L. 2002. The gamma-secretase-generated intracellular domain of beta-amyloid precursor protein binds Numb and inhibits Notch signaling. Proc. Natl. Acad. Sci. U.S.A. 99:7102-7.
  40. Meucci, O, Fatatis, A, Simen, AA, Miller, RJ. 2000. Expression of CX3CR1 chemokine receptors on neurons and their role in neuronal survival. Proc. Natl. Acad. Sci. U.S.A. 97:8075-80.
  41. Miller, RJ, Meucci, O. 1999. AIDS and the brain: is there a chemokine connection?. Trends Neurosci. 22:471-9.
  42. Tran, PB, Meucci, O, Miller, RJ. 1999. HIV-1 and chemokines in the brain: location, location--location?. Mol. Psychiatry 4:203-5, 202.
  43. Meucci, O, Miller, RJ. Dissociation between the Joro spider toxin sensitivity of recombinant alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors and their ability to increase intracellular calcium. Neuropharmacology 37:1431-43.
  44. Meucci, O, Fatatis, A, Simen, AA, Bushell, TJ, Gray, PW, Miller, RJ. 1998. Chemokines regulate hippocampal neuronal signaling and gp120 neurotoxicity. Proc. Natl. Acad. Sci. U.S.A. 95:14500-5.
  45. Scorziello, A, Meucci, O, Calvani, M, Schettini, G. 1997. Acetyl-L-carnitine arginine amide prevents beta 25-35-induced neurotoxicity in cerebellar granule cells. Neurochem. Res. 22:257-65.
  46. Meucci, O, Miller, RJ. 1996. gp120-induced neurotoxicity in hippocampal pyramidal neuron cultures: protective action of TGF-beta1. J. Neurosci. 16:4080-8.
  47. Scorziello, A, Meucci, O, Florio, T, Fattore, M, Forloni, G, Salmona, M, Schettini, G. 1996. beta 25-35 alters calcium homeostasis and induces neurotoxicity in cerebellar granule cells. J. Neurochem. 66:1995-2003.
  48. Meucci, O, Fatatis, A, Holzwarth, JA, Miller, RJ. 1996. Developmental regulation of the toxin sensitivity of Ca(2+)-permeable AMPA receptors in cortical glia. J. Neurosci. 16:519-30.
  49. Ventra, C, Meucci, O, Grimaldi, M, Scorziello, A, Porcellini, A, Schettini, G. 1995. Absence of D2S dopamine receptor in the prolactin-secreting MMQ pituitary clone: characterization of a wild D2L receptor coupled to native transduction mechanisms. J. Mol. Endocrinol. 14:375-89.
  50. Meucci, O, Scorziello, A, Avallone, A, Florio, T, D'Alto, V, Fattore, M, Schettini, G. 1995. Alpha 1 B, but not alpha 1A, adrenoreceptor activates calcium influx through the stimulation of a tyrosine kinase/phosphotyrosine phosphatase pathway, following noradrenaline-induced emptying of IP3 sensitive calcium stores, in PC Cl3 rat thyroid cell line. Biochem. Biophys. Res. Commun. 209:630-8.
  51. Galli, C, Meucci, O, Scorziello, A, Werge, TM, Calissano, P, Schettini, G. 1995. Apoptosis in cerebellar granule cells is blocked by high KCl, forskolin, and IGF-1 through distinct mechanisms of action: the involvement of intracellular calcium and RNA synthesis. J. Neurosci. 15:1172-9.
  52. Ventra, C, Grimaldi, M, Meucci, O, Scorziello, A, Apicella, A, Filetti, E, Marino, A, Schettini, G. 1994. Aniracetam improves behavioural responses and facilitates signal transduction in the rat brain. J. Psychopharmacol. (Oxford) 8:109-17.
  53. Meucci, O, Scorziello, A, Avallone, A, Ventra, C, Grimaldi, M, Berlingieri, MT, Fusco, A, Schettini, G. 1994. Alpha 1A- and alpha 1B-adrenergic receptors mediate the effect of norepinephrine on cytosolic calcium levels in rat PC C13 thyroid cells: thyrotropin modulation of alpha 1B-linked response via a adenosine 3',5'-monophosphate-protein kinase-A-dependent pathway. Endocrinology 134:424-31.
  54. Scorziello, A, Landolfi, E, Grimaldi, M, Meucci, O, Ventra, C, Avallone, A, Postiglione, A, Schettini, G. 1993. Direct effect of adenosine on prolactin secretion at the level of the single rat lactotroph: involvement of pertussis toxin-sensitive and -insensitive transducing mechanisms. J. Mol. Endocrinol. 11:325-34.
  55. Florio, T, Meucci, O, Grimaldi, M, Ventra, C, Cocozza, E, Avallone, A, Postiglione, A, Marino, A, Schettini, G. 1993. Effect of acetyl-L-carnitine treatment on brain adenylate cyclase activity in young and aged rats. Eur Neuropsychopharmacol 3:95-101.
  56. Meucci, O, Berlingieri, MT, Fusco, A, Scorziello, A, Santoro, M, Grieco, M, Grimaldi, M, Schettini, G. 1993. Norepinephrine and thyrotropin stimulation of [Ca++]i in PC C13 a rat thyroid epithelial cell line: effect of transformation by E1A gene adenovirus and polyomavirus middle-T antigen gene. Life Sci. 52:891-9.
  57. Schettini, G, Ventra, C, Florio, T, Grimaldi, M, Meucci, O, Marino, A. 1992. Modulation by GTP of basal and agonist-stimulated striatal adenylate cyclase activity following chronic blockade of D1 and D2 dopamine receptors: involvement of G proteins in the development of receptor supersensitivity. J. Neurochem. 59:1667-74.
  58. Meucci, O, Landolfi, E, Scorziello, A, Grimaldi, M, Ventra, C, Florio, T, Avallone, A, Schettini, G. 1992. Dopamine and somatostatin inhibition of prolactin secretion from MMQ pituitary cells: role of adenosine triphosphate-sensitive potassium channels. Endocrinology 131:1942-7.
  59. Schettini, G, Ventra, C, Florio, T, Grimaldi, M, Meucci, O, Scorziello, A, Postiglione, A, Marino, A. 1992. Molecular mechanisms mediating the effects of L-alpha-glycerylphosphorylcholine, a new cognition-enhancing drug, on behavioral and biochemical parameters in young and aged rats. Pharmacol. Biochem. Behav. 43:139-51.
  60. Meucci, O, Grimaldi, M, Scorziello, A, Govoni, S, Bergamaschi, S, Yasumoto, T, Schettini, G. 1992. Maitotoxin-induced intracellular calcium rise in PC12 cells: involvement of dihydropyridine-sensitive and omega-conotoxin-sensitive calcium channels and phosphoinositide breakdown. J. Neurochem. 59:679-88.
  61. Grimaldi, M, Meucci, O, Scorziello, A, Florio, T, Ventra, C, De Mercato, R, Schettini, G. 1992. Interleukin 6 modulation of second messenger systems in anterior pituitary cells. Life Sci. 51:1243-8.
  62. Schettini, G, Grimaldi, M, Landolfi, E, Meucci, O, Ventra, C, Florio, T, Scorziello, A, Marino, A. 1991. Role of interleukin-6 in the neuroendocrine system. Acta Neurol (Napoli) 13:361-7.
  63. Schettini, G, Meucci, O, Grimaldi, M, Florio, T, Landolfi, E, Scorziello, A, Ventra, C. 1991. Dihydropyridine modulation of voltage-activated calcium channels in PC12 cells: effect of pertussis toxin pretreatment. J. Neurochem. 56:805-11.
  64. Meucci, O, Grimaldi, M, Florio, T, Landolfi, E, Ventra, C, Scorziello, A, Marino, A, Schettini, G. Cytosolic calcium rise induced by maitotoxin in PC12 cells: effect of omega-conotoxin (GVIA). Pharmacol. Res. 22 Suppl 1:75-6.
  65. Grimaldi, M, Landolfi, E, Meucci, O, Florio, T, Ventra, C, Schettini, G, Marino, A. Interleukin 1 beta modulation of TRH stimulated prolactin secretion and inositol phosphate production. Pharmacol. Res. 22 Suppl 1:81-2.
  66. Florio, T, Landolfi, E, Grimaldi, M, Meucci, O, Ventra, C, Scorziello, A, Marino, A, Schettini, G. Interleukin-6 mediates neural-immune interactions: study on prolactin release and intracellular transducing mechanisms. Pharmacol. Res. 22 Suppl 3:54.
  67. Schettini, G, Landolfi, E, Meucci, O, Florio, T, Grimaldi, M, Ventra, C, Marino, A. 1990. Adenosine and its analogue (-)-N6-R-phenyl-isopropyladenosine modulate anterior pituitary adenylate cyclase activity and prolactin secretion in the rat. J. Mol. Endocrinol. 5:69-76.
  68. Schettini, G, Florio, T, Meucci, O, Landolfi, E, Grimaldi, M, Lombardi, G, Scala, G, Leong, D. 1990. Interleukin-1-beta modulation of prolactin secretion from rat anterior pituitary cells: involvement of adenylate cyclase activity and calcium mobilization. Endocrinology 126:1435-41.
  69. Marino, A, Florio, T, Meucci, O, Landolfi, E, Grimaldi, M, Ventra, C, Schettini, G. Fipexide improvement of cognitive functions in rat: behavioural and neurochemical studies. Pharmacol. Res. 22:179-87.
  70. Meucci, O, Grimaldi, M, Landolfi, E, Scorziello, A, Marino, A, Schettini, G. 1990. How maitotoxin increases cytosolic calcium levels?. Acta Physiol Hung 75 Suppl:207-8.
  71. Bergamaschi, S, Trabucchi, M, Battaini, F, Parenti, M, Schettini, G, Meucci, O, Govoni, S. 1990. Modulation of dihydropyridine-sensitive calcium channels: a role for G proteins. Eur. Neurol. 30 Suppl 2:16-20; discussion 39-41.
  72. Schettini, G, Landolfi, E, Grimaldi, M, Meucci, O, Postiglione, A, Florio, T, Ventra, C. 1989. Interleukin 1 beta inhibition of TRH-stimulated prolactin secretion and phosphoinositides metabolism. Biochem. Biophys. Res. Commun. 165:496-505.
  73. Landolfi, E, Meucci, O, Florio, T, Grimaldi, M, Marino, A, Schettini, G. Anterior pituitary adenosine receptors, coupled to adenylate cyclase, modulate prolactin release. Pharmacol. Res. 21 Suppl 1:5-6.
  74. Florio, T, Meucci, O, Landolfi, E, Grimaldi, M, Ventra, C, Scorziello, A, Marino, A, Schettini, G. Interleukin I modulation of anterior pituitary function: effect on hormone release and second messenger systems. Pharmacol. Res. 21 Suppl 1:35-6.
  75. Meucci, O, Grimaldi, M, Florio, T, Landolfi, E, Scorziello, A, Ventra, C, Marino, A, Schettini, G. Dihydropiridine inhibition of K+ and maitotoxin stimulated calcium fluxes in PC12 cells: effect of pertussis toxin. Pharmacol. Res. 21 Suppl 1:1-2.
  76. Schettini, G, Florio, T, Meucci, O, Landolfi, E, Grimaldi, M, Ventra, C, Marino, A. 1989. Somatostatin inhibition of adenylate cyclase activity in different brain areas. Brain Res. 492:65-71.
  77. Landolfi, E, Florio, T, Meucci, O, Grimaldi, M, Magri, G, Leong, DA, Schettini, G. 1988. Steroid modulation of prolactin release from single lactotropes in male and female rats studied by the reverse hemolytic plaque assay. Pharmacol Res Commun 20:1075-6.
  78. Meucci, O, Florio, T, Grimaldi, M, Landolfi, E, Magri, G, Schettini, G. 1988. Role of G-proteins in mediating dihydropyridine receptor coupling with voltage sensitive calcium channels. Pharmacol Res Commun 20:1083-4.
  79. Schettini, G, Florio, T, Meucci, O, Scala, G, Landolfi, E, Grimaldi, M. 1988. Effect of interleukin 1 beta on transducing mechanisms in 235-1 clonal pituitary cells. Part I: Modulation of adenylate cyclase activity. Biochem. Biophys. Res. Commun. 155:1089-96.
  80. Schettini, G, Meucci, O, Florio, T, Scala, G, Landolfi, E, Grimaldi, M. 1988. Effect of interleukin 1 beta on transducing mechanisms in 235-1 clonal pituitary cells. Part II: Modulation of calcium fluxes. Biochem. Biophys. Res. Commun. 155:1097-104.
  81. Schettini, G, Florio, T, Magri, G, Grimaldi, M, Meucci, O, Landolfi, E, Marino, A. 1988. Somatostatin and SMS 201-995 reverse the impairment of cognitive functions induced by cysteamine depletion of brain somatostatin. Eur. J. Pharmacol. 151:399-407.
  82. Schettini, G, Meucci, O, Florio, T, Grimaldi, M, Landolfi, E, Magri, G, Yasumoto, T. 1988. Pertussis toxin pretreatment abolishes dihydropyridine inhibition of calcium flux in the 235-1 pituitary cell line. Biochem. Biophys. Res. Commun. 151:361-9.
  83. Schettini, G, Florio, T, Meucci, O, Landolfi, E, Lombardi, G, Marino, A. 1988. Somatostatin inhibition of anterior pituitary adenylate cyclase activity: different sensitivity between male and female rats. Brain Res. 439:322-9.
  84. Schettini, G, Florio, T, Meucci, O, Landolfi, E, Cronin, MJ, MacLeod, RM. 1987. Calmodulin modulates prolactin secretion in vitro: studies with calmodulin containing liposomes. Life Sci. 41:2437-44.
Search PubMed