New publication on US9 fusion proteins to control amyloidogenesis

Dr. Renato Brandimarti and colleagues from the lab published a new study detailing US9 fusion proteins that control amyloid precursor protein processing without targeting endogenous secretases. The work was published in Molecular Neurobiology and is freely available.

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Us9 controls APP

The US9 fusion protein gPTG9TM pulls APP away from sites of B-cleavage, which produces more neuroprotective soluble α-APP and improves several markers related to Alzheimer’s disease.