New publication on US9 fusion proteins to control amyloidogenesis

Dr. Renato Brandimarti and colleagues from the lab published a new study detailing US9 fusion proteins that control amyloid precursor protein processing without targeting endogenous secretases. The work was published in Molecular Neurobiology and is freely available.

Click here to read the publication!

 

Us9 controls APP

The US9 fusion protein gPTG9TM pulls APP away from sites of B-cleavage, which produces more neuroprotective soluble α-APP and improves several markers related to Alzheimer’s disease.