The Meucci lab published a book chapter on known and potential mechanisms by which µ-opioid agonists regulate neuronal iron homeostasis, a new finding that has implications for HIV-associated neurocognitive disorders and other neurological disorders. The chapter expands on previous work from our lab showing that morphine regulates iron storage in endolysosomes, and this leads to dendritic spine deficits in cortical neurons. In addition, the chapter covers known and probable molecular mechanisms for morphine regulation of endolysosomal iron stores, implications for other iron-related proteins including amyloid precursor protein (APP), and a new approach to determine if µ-opioid agonists regulate APP expression or processing.
This chapter was published in the second edition of the book “Opioid Receptors”, and an illustration from our chapter inspired the book cover art. The book is a part of the Methods in Molecular Biology book series.
The abstract of the book chapter is available here.